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Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease

19 May 2025

Abstract excerpt

Trisomy of chromosome 21, the cause of Down syndrome (DS), is the most commonly occurring genetic cause of Alzheimer's disease (AD). Here, we compare the frontal cortex proteome of people with Down syndrome-Alzheimer's disease (DSAD) to demographically matched cases of early onset AD and healthy ageing controls. We find dysregulation of the proteome, beyond proteins encoded by chromosome 21, including an increase...

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PMID: 40387921
DOI: 10.1007/s00401-025-02889-0

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