Article

Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex

2025-07-04

Abstract excerpt

Down syndrome is the most common genetic cause of intellectual disability and is characterized by early-onset delays in motor, cognitive, and language development. The molecular mechanisms underlying these neurodevelopmental impairments remain poorly understood. Here, we utilized single-nucleus multiomic sequencing to simultaneously profile gene expression and chromatin accessibility in the Down syndrome prefronta...

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Literature Corpus work: 1a987e09-89fc-5348-ad96-7b3ce5617ac6
DOI: 10.1101/2025.06.30.662385

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