Article

Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer’s disease

2025-02-25

Abstract excerpt

Trisomy of chromosome 21, the cause of Down syndrome (DS), is the most commonly occurring genetic cause of Alzheimer’s disease (AD). Here, we compare the frontal cortex proteome of people with Down syndrome-Alzheimer’s disease (DSAD) to demographically matched cases of early-onset AD and healthy ageing controls. We find wide dysregulation of the proteome, beyond proteins encoded by chromosome 21, including an incr...

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Literature Corpus work: 81443638-b162-5d4b-81b2-c6eeb62795b9
DOI: 10.1101/2025.02.24.639862

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