Article

NLRX1 is an essential, druggable regulator of mitochondrial permeability transition

2026-08-26

Abstract excerpt

The molecular composition of the mitochondrial permeability transition pore (mPTP) remains contested, and several efficacious mPTP inhibitors act through undefined, cyclophilin D (CypD)-independent targets. Using two structurally distinct chemotypes of optimised, brain-penetrant mPTP inhibitors as chemical probes, we applied affinity-based chemoproteomics to identify the mitochondrial NOD-like receptor NLRX1 as th...

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Literature Corpus work: b32210fd-6257-5e90-8e68-bb62e3f1cf74
DOI: 10.64898/2026.08.24.746860

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