Article

A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesis

2023-11-10

Abstract excerpt

<h4>Objective</h4> We sought to create and characterize a mouse model of the inflammatory, cerebral demyelinating phenotype of X-linked adrenoleukodystrophy (ALD) that would facilitate the study of disease pathogenesis and therapy development. We also sought to cross-validate potential therapeutic targets such as fibrin, oxidative stress, and the NLRP3 inflammasome, in post-mortem human and murine brain tissues....

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Literature Corpus work: 86a08acc-38ef-5d51-b924-993727fe6cf1
DOI: 10.1101/2023.11.07.564025

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