Article

MCC950/CRID3 potently targets the NACHT domain of wildtype NLRP3 but not disease-associated mutants for inflammasome inhibition

2019-05-11

Abstract excerpt

<h4>Summary</h4> The NLRP3 inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant and neurodegenerative diseases. Additionally, NLRP3 gain-of-function point mutations cause systemic periodic fever syndromes that are collectively known as cryopyrin-associated periodic syndromes (CAPS). There is significant interest in the discovery and development of diarylsulfonylurea Cytoki...

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Literature Corpus work: b32f0260-679c-5d0f-9b48-0cffa70b4863
DOI: 10.1101/634493

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