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New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer’s disease

26 Dec 2023

Abstract excerpt

Mitochondrial dysfunction is an early pathological feature of Alzheimer disease and plays a crucial role in the development and progression of Alzheimer's disease. Strategies to rescue mitochondrial function and cognition remain to be explored. Cyclophilin D (CypD), the peptidylprolyl isomerase F (PPIase), is a key component in opening the mitochondrial membrane permeability transition pore, leading to...

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PMID: 38146639
DOI: 10.1093/brain/awad432

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