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Article

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.

The Journal of biological chemistry - 26 Feb 2016

Warne Justin, Pryce Gareth, Hill Julia M, Shi Xiao, Lennerås Felicia, Puentes Fabiola, Kip Maarten, Hilditch Laura, Walker Paul, Simone Michela I, Chan A W Edith, Towers Greg J, Coker Alun R, Duchen Michael R, Szabadkai Gyorgy, Baker David, Selwood David L

Abstract excerpt

The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart. The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of the pore, and genetic down-regulation or knock-out improves outcomes in disease models. Current inhibitors of peptidylprolyl isomerases...

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Identifiers

PMID: 26679998
DOI: 10.1074/jbc.M115.700385
PMCID: PMC4813465

Genes

PPIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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