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Article

Modeling-Enabled Characterization of Novel NLRX1 Ligands.

PloS one - 1 Jan 2015

Lu Pinyi, Hontecillas Raquel, Abedi Vida, Kale Shiv, Leber Andrew, Heltzel Chase, Langowski Mark, Godfrey Victoria, Philipson Casandra, Tubau-Juni Nuria, Carbo Adria, Girardin Stephen, Uren Aykut, Bassaganya-Riera Josep

Abstract excerpt

Nucleotide-binding domain and leucine-rich repeat containing (NLR) family are intracellular sentinels of cytosolic homeostasis that orchestrate immune and inflammatory responses in infectious and immune-mediated diseases. NLRX1 is a mitochondrial-associated NOD-like receptor involved in the modulation of immune and metabolic responses. This study utilizes molecular docking approaches to investigate the structure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26714018
DOI: 10.1371/journal.pone.0145420
PMCID: PMC4694766

Genes

NLRX1
SPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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