Article
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor.
Nature communications - 26 Feb 2026
Hardy Emily P, Haider A Nasim, Patel Maulin M, Nesin Vasyl, Hoang Hanh T M, Gostynska Sandra E, Berry William L, Pioszak Augen A, Ahmad Mohiuddin, Parnell Stephen C, Tsiokas Leonidas
Abstract excerpt
The human genome contains approximately 800 G protein-coupled receptors (GPCRs), all characterized by a common 7-transmembrane domain architecture. Here, we show that PKD1, an 11-transmembrane protein with a noncanonical transient receptor potential (TRP) channel architecture, functions as a GPCR with unique biochemical properties. PKD1 acts as a WNT-activated receptor, directly coupling to heterotrimeric Gαi1-3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.