Article

Quantifying the Influence of Mutation Detection on Tumour Subclonal Reconstruction

2018-09-17

Abstract excerpt

Whole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumoural heterogeneity is linked to clinical outcomes. Many algorithms have been developed for subclonal reconstruction, but their variabilities and consistencies are largely unknown. We evaluated sixteen pipelines for reconstructing the evolutionary histories of 293 localized prostate cancers from single samples, and e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b309439c-76d7-52af-9425-46b7197a3c82
DOI: 10.1101/418780

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantifying the Influence of Mutation Detection on Tumour Subclonal ReconstructionDOI 10.1101/418780Read

Quantifying the influence of mutation detection on tumour subclonal reconstruction.Semantic proximity Read

Principles of Reconstructing the Subclonal Architecture of Cancers.Semantic proximity Read

A practical guide to cancer subclonal reconstruction from DNA sequencing.Semantic proximity Read

Creating Standards for Evaluating Tumour Subclonal ReconstructionSemantic proximity Read

A community effort to create standards for evaluating tumor subclonal reconstruction.Semantic proximity Read

Longitudinal structural variant phylogenies define tumor evolution under therapeutic selection pressure in metastatic prostate cancerSemantic proximity Read

Reconstructing tumor clonal heterogeneity and evolutionary relationships based on tumor DNA sequencing data.Semantic proximity Read

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers.Semantic proximity Read

Model-based tumor subclonal reconstructionSemantic proximity Read

Estimation of cancer cell fractions and clone trees from multi-region sequencing of tumors.Semantic proximity Read

Estimation of cancer cell fractions and clone trees from multi-region sequencing of tumorsSemantic proximity Read

PhyloWGS: reconstructing subclonal composition and evolution from whole-genome sequencing of tumors.Semantic proximity Read