Article
A community effort to create standards for evaluating tumor subclonal reconstruction.
Nature biotechnology - 1 Jan 2020
Salcedo Adriana, Tarabichi Maxime, Espiritu Shadrielle Melijah G, Deshwar Amit G, David Matei, Wilson Nathan M, Dentro Stefan, Wintersinger Jeff A, Liu Lydia Y, Ko Minjeong, Sivanandan Srinivasan, Zhang Hongjiu, Zhu Kaiyi, Ou Yang Tai-Hsien, Chilton John M, Buchanan Alex, Lalansingh Christopher M, P'ng Christine, Anghel Catalina V, Umar Imaad, Lo Bryan, Zou William, Simpson Jared T, Stuart Joshua M, Anastassiou Dimitris, Guan Yuanfang, Ewing Adam D, Ellrott Kyle, Wedge David C, Morris Quaid, Van Loo Peter, Boutros Paul C
Abstract excerpt
Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogeneity to infer evolutionary dynamics. A growing number of studies have used these approaches to link cancer evolution with clinical progression and response to therapy. Although the inference of tumor phylogenies is rapidly becoming standard practice in cancer genome analyses, standards for evaluating them are...
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