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Article

A practical guide to cancer subclonal reconstruction from DNA sequencing.

Nature methods - 1 Feb 2021

Tarabichi Maxime, Salcedo Adriana, Deshwar Amit G, Ni Leathlobhair Máire, Wintersinger Jeff, Wedge David C, Van Loo Peter, Morris Quaid D, Boutros Paul C

Abstract excerpt

Subclonal reconstruction from bulk tumor DNA sequencing has become a pillar of cancer evolution studies, providing insight into the clonality and relative ordering of mutations and mutational processes. We provide an outline of the complex computational approaches used for subclonal reconstruction from single and multiple tumor samples. We identify the underlying assumptions and uncertainties in each step and...

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Identifiers

PMID: 33398189
DOI: 10.1038/s41592-020-01013-2
PMCID: PMC7867630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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