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Article

Quantifying the influence of mutation detection on tumour subclonal reconstruction.

Nature communications - 7 Dec 2020

Liu Lydia Y, Bhandari Vinayak, Salcedo Adriana, Espiritu Shadrielle M G, Morris Quaid D, Kislinger Thomas, Boutros Paul C

Abstract excerpt

Whole-genome sequencing can be used to estimate subclonal populations in tumours and this intra-tumoural heterogeneity is linked to clinical outcomes. Many algorithms have been developed for subclonal reconstruction, but their variabilities and consistencies are largely unknown. We evaluate sixteen pipelines for reconstructing the evolutionary histories of 293 localized prostate cancers from single samples, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33288765
DOI: 10.1038/s41467-020-20055-w
PMCID: PMC7721877

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