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Article

Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers.

PloS one - 1 Jan 2025

Erickson Andrew, Figiel Sandy, Rajakumar Timothy, Rao Srinivasa, Yin Wencheng, Doultsinos Dimitrios, Magnussen Anette, Singh Reema, Poulose Ninu, Bryant Richard J, Cussenot Olivier, Hamdy Freddie C, Woodcock Dan, Mills Ian G, Lamb Alastair D

Abstract excerpt

Epithelial cancers are typically heterogeneous with primary prostate cancer being a typical example of histological and genomic variation. Prior studies of primary prostate cancer tumour genetics revealed extensive inter and intra-patient genomic tumour heterogeneity. Recent advances in machine learning have enabled the inference of ground-truth genomic single-nucleotide and copy number variant status from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39752458
DOI: 10.1371/journal.pone.0316475
PMCID: PMC11698422

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