Article

Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

2021-03-02

Abstract excerpt

Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular identity loss. Our analysis of cerebral cortex, lung, liver and muscle transcriptomes of 16 mice, covering development and ageing intervals, revealed widespread but tissue-specific ageing-associated expression reversals. Cumulatively, these reversals create a unique phenomenon: mam...

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Literature Corpus work: b3090238-f745-5a20-9d4a-35ec68470a6d
DOI: 10.1101/2021.03.02.432281

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