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A MOUSE ORGANOID PLATFORM FOR MODELING CEREBRAL CORTEX DEVELOPMENT AND CIS-REGULATORY EVOLUTION IN VITRO

2024-10-01

Abstract excerpt

<h4>SUMMARY</h4> Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular and cellular mechanisms driving phenotypic changes have proven difficult to characterize. Here, we develop a reproducible protocol to generate neocortical organoids from mouse epiblast stem cells (EpiSC...

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Literature Corpus work: 6fc225fc-b482-56d6-b58c-74f3af36a2a8
DOI: 10.1101/2024.09.30.615887

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