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Transcriptomic analysis reveals a tissue-specific loss of identity during ageing and cancer

26 Oct 2023

Abstract excerpt

INTRODUCTION: Understanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes in human tissues are associated with tissue specificity during cancer and ageing using transcriptome data from TCGA and GTEx. RESULTS: We found significant downregulation of tissue-specific genes during ageing in 40% of the tissues analyzed, which suggests loss of...

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PMID: 37884865
DOI: 10.1186/s12864-023-09756-w

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