Mutation accumulation differentially impacts ageing in mammalian tissues

Abstract excerpt

Medawar’s mutation accumulation (MA) hypothesis explains ageing by the declining force of natural selection with age: slightly deleterious germline mutations that are functional in old age are not effectively eliminated by selection and therefore lead to ageing-related phenotypes. Although widely cited, empirical support for the MA hypothesis, particularly molecular evidence, has remained limited. Here we test one...

Topics

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• Phenotype
• Adipose Tissue and Metabolism
• Aging
• Gene Expression
• Gene Expression Regulation
• Genetics, Aging, and Longevity in Model Organisms
• Molecular Biology Techniques and Applications
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

acd832db-ec38-5243-9c6e-9b8c744e23b3

DOI

10.1101/247700