Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

Abstract excerpt

Aging is accompanied by the functional decline of tissues. However, a systematic study of epigenomic and transcriptomic changes across tissues during aging is missing. Here we generated chromatin maps and transcriptomes from 4 tissues and one cell type from young, middle-age, and old mice, yielding 143 high-quality datasets. We focused specifically on chromatin marks linked to gene expression regulation and cell i...

Topics

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• CD4-Positive T-Lymphocytes
• Cellular Senescence
• Immunologic Memory
• Lymphocyte Activation
• Receptors, Antigen, T-Cell
• Sequence Analysis, RNA
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

dd0f0cc3-06f2-5db4-8952-dc65a66a1717

DOI

10.1101/336172