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Pan-cancer transcriptomic analysis reveals a tissue-specific loss of identity

2022-12-14

Abstract excerpt

Understanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes in human tissues are associated with tissue specificity during cancer and ageing using transcriptome data from TCGA and GTEx. We found a loss of cell identity during ageing in around 40% of tissues. In cancer, we observed a pattern of downregulation of genes specific to the tiss...

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Literature Corpus work
03f6767a-6ea6-5ac1-9320-cde0e79deb2f
DOI
10.1101/2022.12.12.520045
Open publication

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Pan-cancer transcriptomic analysis reveals a tissue-specific loss of identityDOI 10.1101/2022.12.12.520045
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