Article

CRISPR enriches for cells with mutations in a p53-related interactome, and this can be inhibited

2021-03-10

Abstract excerpt

CRISPR/Cas9 can be used to inactivate or modify genes by inducing double-stranded DNA breaks 1–3 . As a protective cellular response, DNA breaks result in p53-mediated cell cycle arrest and activation of cell death programs 4,5 . Inactivating p53 mutations are the most commonly found genetic alterations in cancer, highlighting the important role of the gene 6–8 . Here, we show that cells deficient in p53, as w...

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Literature Corpus work: b2fa28eb-c626-5c9d-ac5e-c8cacc6efc66
DOI: 10.1101/2021.03.10.434760

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