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Article

Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?

Genes - 25 Jun 2020

Mirgayazova Regina, Khadiullina Raniya, Chasov Vitaly, Mingaleeva Rimma, Miftakhova Regina, Rizvanov Albert, Bulatov Emil

Abstract excerpt

The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence. In many cases, alterations (e.g., mutations of the TP53 gene) negatively affect these pathways resulting in tumor development. Recent advances in genome manipulation technologies, CRISPR/Cas9, in...

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Identifiers

PMID: 32630614
DOI: 10.3390/genes11060704
PMCID: PMC7349023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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