Article
CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies.
Cancer research - 1 Jan 2022
Jiang Long, Ingelshed Katrine, Shen Yunbing, Boddul Sanjaykumar V, Iyer Vaishnavi Srinivasan, Kasza Zsolt, Sedimbi Saikiran, Lane David P, Wermeling Fredrik
Abstract excerpt
Inactivating p53 mutations are the most abundant genetic alterations found in cancer. Here we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient in p53 and in genes of a core CRISPR-p53 tumor suppressor interactome. Such enrichment could predispose to cancer development and thus pose a challenge for clinical CRISPR use. Transient p53 inhibition could suppress the enrichment of...
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