Article

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding

2026-05-09

Abstract excerpt

Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ∼40-50% of cases 1,2 . However, current therapies fail to target most such mutations because the mutant proteins typically lack defined drug-binding pockets, and restoring the endogenous function has proven challenging. Here, we programmed CRISPR-Cas12a2, an RNA-guided nuclease...

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Literature Corpus work: 507e5423-a88d-5a4f-a182-994cedfbd7c9
DOI: 10.64898/2026.05.08.723607

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