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Integrated computational and experimental identification of p53, KRAS and VHL mutant selection associated with CRISPR-Cas9 editing

2018-09-03

Abstract excerpt

Recent studies have reported that CRISPR-Cas9 gene editing induces a p53 -dependent DNA damage response in primary cells, which may select for cells with oncogenic p53 mutations 11,12 . It is unclear whether these CRISPR-induced changes are applicable to different cell types, and whether CRISPR gene editing may select for other oncogenic mutations. Addressing these questions, we analyzed genome-wide CRISPR and...

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Literature Corpus work: dd944685-7d5f-5c49-919a-2a86c89f88d2
DOI: 10.1101/407767

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Integrated computational and experimental identification of <i>p53, KRAS</i> and <i>VHL</i> mutant selection associated with CRISPR-Cas9 editing

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