Article

Therapeutic Interruption of T Cell Development Generates High-Affinity T Cells That Escape Exhaustion and Improve Cancer Immunotherapy

2022-01-21

Abstract excerpt

<h4>SUMMARY</h4> Availability of effective anti-tumor T cells is limited by cancer immunoediting, which depletes neoantigens, and central tolerance, which eliminates developing T cells with high-affinity T cell receptors (TCRs) against tumor self-antigens. Remaining tumor-reactive T cells are often exhausted after immune checkpoint blockade (ICB). Whether endogenous T cells with high- affinity TCRs against tumor...

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Literature Corpus work: fa270093-884d-5dbd-85e1-d060b549fc54
DOI: 10.1101/2022.01.19.476935

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