Article

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

2019-03-03

Abstract excerpt

Neurotrophins are critically involved in regulating in normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated in the progression of several types of cancer. However, its role in medulloblastoma (MB), the most common type of malignant brain tumor afflicting children, remain...

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Literature Corpus work: b2e36745-3442-5296-a39c-1de2b1dd840b
DOI: 10.1101/566000

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