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Article

The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.

Neuro-oncology - 1 Sept 2011

Oehler Christoph, von Bueren André O, Furmanova Polina, Broggini-Tenzer Angela, Orlowski Katrin, Rutkowski Stefan, Frei Karl, Grotzer Michael A, Pruschy Martin

Abstract excerpt

Concurrent radiochemotherapy for medulloblastoma includes the microtubule disrupting agent vincristine; however, vincristine alone or as part of a combined treatment regimen is highly toxic. A major goal is therefore to replace vincristine with novel potent chemotherapeutic agents-in particular, with microtubule stabilizing and destabilizing compounds-with a larger therapeutic window. Here, we investigated the...

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Identifiers

PMID: 21743064
DOI: 10.1093/neuonc/nor069
PMCID: PMC3158010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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