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Article

High-affinity neurotrophin receptors and ligands promote leukemogenesis

5 Dec 2008

Abstract excerpt

Neurotrophins (NTs) and their receptors play a key role in neurogenesis and survival. The TRK (tropomyosin-related kinase) receptor protein tyrosine kinases (TRKA, TRKB, TRKC) are high-affinity NT receptors that are expressed in a variety of human tissues. Their role in normal and malignant hematopoiesis is poorly understood. In a prospective study involving 94 adult patients we demonstrate for the first time...

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Identifiers

PMID: 19059881
DOI: 10.1182/blood-2008-05-155200

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