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Article

Trk Receptor Expression and Inhibition in Neuroblastomas

6 May 2009

Abstract excerpt

Neuroblastoma, the most common and deadly solid tumor in children, exhibits heterogeneous clinical behavior, from spontaneous regression to relentless progression. Current evidence suggests that the TRK family of neurotrophin receptors plays a critical role in these diverse behaviors. Neuroblastomas expressing TrkA are biologically favorable and prone to spontaneous regression or differentiation, depending on the...

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PMID: 19417027
DOI: 10.1158/1078-0432.ccr-08-1815

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