Article

Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma

2020-02-04

Abstract excerpt

<h4>Background</h4> A member of the Trk family of neurotrophin receptors, tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene) is an increasingly important target in various cancer types, including glioblastoma (GBM). EGFR is among the most frequently altered oncogenes in GBM, and EGFR inhibition has been tested as an experimental therapy. Functional interactions between EGFR and TrkB have been demon...

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Literature Corpus work: 2f9bdef6-f38b-5306-9580-7886f621ac86
DOI: 10.1101/2020.02.03.932608

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