Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BDNF: An Oncogene or Tumor Suppressor?

20 Jul 2017

Abstract excerpt

Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development and differentiation. It has also been shown to protect several neuronal cell types from an array...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Neuroblastoma Research and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28739680
DOI: 10.21873/anticanres.11783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BDNF: An Oncogene or Tumor Suppressor?PMID 28739680Read ↗

Perspectives on miRNAs directly targeting BDNF for cancer diagnosis and treatment (Review)Semantic proximity Read ↗

On<i>Trk</i>—The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer BiologySemantic proximity Read ↗

Trk Receptor Expression and Inhibition in NeuroblastomasSemantic proximity Read ↗

Expression of brain-derived neurotrophic factor and its receptor TrkB is associated with poor prognosis and a malignant phenotype in small cell lung cancer.Semantic proximity Read ↗

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in MedulloblastomaSemantic proximity Read ↗

Genetic and Pharmacologic Identification of Akt as a Mediator of Brain-Derived Neurotrophic Factor/TrkB Rescue of Neuroblastoma Cells from Chemotherapy-Induced Cell DeathSemantic proximity Read ↗

Expression and pharmacological inhibition of TrkB and EGFR in glioblastomaSemantic proximity Read ↗

BDNF-TrkB signaling and neuroprotection in schizophrenia.Semantic proximity Read ↗

High-affinity neurotrophin receptors and ligands promote leukemogenesisSemantic proximity Read ↗

Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo.Semantic proximity Read ↗

The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.Semantic proximity Read ↗

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.