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Article

Brain-derived neurotrophic factor promotes survival and chemoprotection of human neuroblastoma cells.

The Journal of biological chemistry - 4 Jun 1999

Middlemas D S, Kihl B K, Zhou J, Zhu X

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) promotes neuronal survival and protection against neuronal damage. We addressed whether BDNF might promote survival and chemoprotection in neuroblastoma (NB) using a drug-sensitive human NB cell line. All-trans-retinoic acid (ATRA) induces a striking phenotypic differentiation of NB1643 cells, and exogenous BDNF treatment promotes survival of these differentiated cells....

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Source

Identifiers

PMID: 10347207
DOI: 10.1074/jbc.274.23.16451

Genes

BDNF
FOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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