Article

ProteoMapper: Alignment-Aware Identification and Quantitative Analysis of Contextual Motif–Domain Patterns in Protein Families

2026-02-20

Abstract excerpt

Protein function depends on interactions between structural domains and regulatory motifs. Yet current tools analyze these elements separately, hindering investigation of disease mutations affecting evolutionarily conserved, structurally constrained motifs. We present ProteoMapper, a computational framework integrating HMMER-based domain annotation with user-defined motif detection to quantify motif-domain spatial...

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Literature Corpus work: b2d41a64-c653-5d6e-ab1b-f448bdb38920
DOI: 10.64898/2026.02.17.706295

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