Article

Accurate Protein Domain Structure Annotation with DomainMapper

2022-03-20

Abstract excerpt

<h4>SUMMARY</h4> Automated domain annotation plays a number of important roles in structural informatics and typically involves searching query sequences against Hidden Markov Model (HMM) profiles. This process can be ambiguous or inaccurate when proteins contain domains with non-contiguous residue ranges, and especially when insertional domains are hosted within them. Here we present DomainMapper, an algorithm t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01e4adfa-7155-5db4-8f13-0c2436880f4e
DOI: 10.1101/2022.03.19.484986

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Accurate Protein Domain Structure Annotation with DomainMapperDOI 10.1101/2022.03.19.484986Read

Clustering predicted structures at the scale of the known protein universeSemantic proximity Read

Clustering predicted structures at the scale of the known protein universeSemantic proximity Read

Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2Semantic proximity Read

Systematic domain-based aggregation of protein structures highlights DNA-, RNA-, and other ligand-binding positionsSemantic proximity Read

Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structuresSemantic proximity Read

An atlas of protein homo-oligomerization across domains of lifeSemantic proximity Read

Characterizing and explaining impact of disease-associated mutations in proteins without known structures or structural homologuesSemantic proximity Read

Characterizing and explaining the impact of disease-associated mutations in proteins without known structures or structural homologs.Semantic proximity Read

Accurate Identification of Functional Residues Across the Human Proteome with TAMALESemantic proximity Read

Real or fake? Verifying protein domain gain and loss events by an automated fact-checking approachSemantic proximity Read

fastCDS: proteome-scale mapping of protein domains to genomic coordinatesSemantic proximity Read

Expansion of the RNAStructuromeDB to include secondary structural data spanning the human protein-coding transcriptomeSemantic proximity Read