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Article

Three-dimensional genome structures of single diploid human cells.

Science (New York, N.Y.) - 31 Aug 2018

Tan Longzhi, Xing Dong, Chang Chi-Han, Li Heng, Xie X Sunney

Abstract excerpt

Three-dimensional genome structures play a key role in gene regulation and cell functions. Characterization of genome structures necessitates single-cell measurements. This has been achieved for haploid cells but has remained a challenge for diploid cells. We developed a single-cell chromatin conformation capture method, termed Dip-C, that combines a transposon-based whole-genome amplification method to detect...

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Identifiers

PMID: 30166492
DOI: 10.1126/science.aat5641
PMCID: PMC6360088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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