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Article

Integrative HLA typing of tumor and adjacent normal tissue can reveal insights into the tumor immune response.

BMC medical genomics - 27 Jan 2024

Sverchkova Angelina, Burkholz Scott, Rubsamen Reid, Stratford Richard, Clancy Trevor

Abstract excerpt

BACKGROUND: The HLA complex is the most polymorphic region of the human genome, and its improved characterization can help us understand the genetics of human disease as well as the interplay between cancer and the immune system. The main function of HLA genes is to recognize "non-self" antigens and to present them on the cell surface to T cells, which instigate an immune response toward infected or transformed...

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Identifiers

PMID: 38281021
DOI: 10.1186/s12920-024-01808-8
PMCID: PMC10821267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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