Article

HLA allele-specific expression loss in tumors can shorten survival and hinder immunotherapy

2020-10-04

Abstract excerpt

Efficient presentation of aberrant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune detection and killing of cancer cells. Patient HLA-I genotypes are known to impact the efficacy of cancer immunotherapy, and the somatic loss of HLA-I heterozygosity has been established as a factor in immune evasion. While global deregulated expression of HLA-I has been reported in dif...

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Literature Corpus work: 45523518-f2ed-5f70-a3bc-fd5f6170bace
DOI: 10.1101/2020.09.30.20204875

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