Article
Activation of the integrated stress response during T helper cell differentiation.
Nature immunology - 1 Jun 2006
Scheu Stefanie, Stetson Daniel B, Reinhardt R Lee, Leber Jess H, Mohrs Markus, Locksley Richard M
Abstract excerpt
Adaptive immune responses require clonal expansion and differentiation of naive T cells into cytokine-secreting effector cells. After priming via signals through the T cell receptor, naive T helper cells express cytokine mRNA but do not secrete cytokine protein without additional T cell receptor stimulation. Here we show that primed T cells demonstrated phosphorylation of eukaryotic initiation factor 2-alpha...
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