Article

Human promoter CpG islands contain primate-specific repeats, cluster and resist reprogramming

2024-03-11

Abstract excerpt

<title>Abstract</title> <p>Imperfect tandem repeats (TRs) of ≥400nt are associated with 365 human 5’-genic CpG islands (TR-CGIs). Most are clustered at chromosome ends, with a high density across chromosome 19. These genes are enriched in neurodevelopmental/behavioral disorders and show interindividual variation in methylation levels. A subset of TR-CGIs is highly methylated and remains so during reprogramming to...

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Literature Corpus work: 3fc9b7c2-f3b5-50e6-8c41-fc5dd3746546
DOI: 10.21203/rs.3.rs-3973757/v1

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