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Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells

2025-10-19

Abstract excerpt

<h4>SUMMARY</h4> Transcriptional regulation of transposons and genes by TRIM28 and 5mC is critical for proper mammalian embryonic development, but the specific roles for these mediators in human embryonic and placental lineage remain unclear. We find that loss of TRIM28 has a limited effect on global transposon expression and instead results in upregulation of genes proximal to TRIM28-bound Long Terminal Repeats...

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Literature Corpus work
9b283346-0274-5e20-9b44-5b3ff550be64
DOI
10.1101/2025.10.19.683051
Open publication

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Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cellsDOI 10.1101/2025.10.19.683051
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