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Article

Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

26 Jun 2023

Abstract excerpt

Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein has been shown to exacerbate neurodegeneration, yet the role of central nervous system (CNS) resident macrophages in this process remains unclear. We found that a specific subset of CNS resident macrophages, border-associated macrophages (BAMs),...

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PMID: 37365181
DOI: 10.1038/s41467-023-39060-w

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