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Article

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease.

Biochemical and biophysical research communications - 23 May 2018

Zhang Youwen, Feng Shujun, Nie Kun, Li Yan, Gao Yuyuan, Gan Rong, Wang Limin, Li Bing, Sun Xuegang, Wang Lijuan, Zhang Yuhu

Abstract excerpt

Neuroinflammation and overactivated microglia underlies the pathogenesis of Parkinson's disease (PD). Furthermore, microglia could polarize into classic inflammatory M1 and immunosuppressive M2 phenotype. Thus, inhibiting the overactivated inflammatory M1 microglia by promoting the transformation of microglia to the protective M2 phenotype provides potential therapy for PD, but the mechanism that modulates...

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Source

Identifiers

PMID: 29621548
DOI: 10.1016/j.bbrc.2018.03.226

Genes

TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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