Article

Müller glial Kir4.1 channel Dysfunction in <i>APOE4</i> -KI model of Alzheimer’s disease

2025-02-28

Abstract excerpt

Alzheimer’s disease (AD), particularly late-onset AD (LOAD), affects millions worldwide, with the apolipoprotein ε4 ( APOE4 ) allele being a significant genetic risk factor. Retinal abnormalities are a hallmark of LOAD, and our recent study demonstrated significant age-related retinal impairments in APOE4 -knock-in (KI) mice, highlighting that retinal impairments occur before the onset of cognitive decline in th...

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Literature Corpus work: b1ec51f9-35f2-5bd1-aaf3-50740a1b44fd
DOI: 10.1101/2025.02.26.640427

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