Article

APOE Impacts Lipid Trafficking in Retinal Pigment Epithelium Cells

2024-05-30

Abstract excerpt

Age-related macular degeneration (AMD) is typified by the formation of lipid-rich drusen under the retinal pigment epithelium (RPE) layer. Apolipoprotein E (APOE) is a known genetic risk factor for AMD and a substantial component of drusen, however, the mechanism by which APOE variants contribute to AMD pathology remains unclear. APOE is the primary cholesterol and lipid transport protein of the central nervous sy...

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Literature Corpus work: b1047bec-f6f7-5056-8fdf-37223de3406d
DOI: 10.1101/2024.05.30.596647

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