Article

<i>Arhgef18</i> is a component of the outer limiting membrane required for retinal homeostasis

2025-10-07

Abstract excerpt

Biallelic ARHGEF18 mutations cause human adult-onset retinal degeneration. We now find that Arhgef18 associates with the retinal outer limiting membrane (OLM), an adherens junction between Müller glia and photoreceptors. Arhgef18 knockout in Müller glial cells led to OLM disruption and vision loss by P60. While mice developed morphologically normal retinas, retinal rosettes started to form by P8, and retinas the...

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Literature Corpus work: b9e6c739-44b5-5bd0-aa08-4446a30d6b7a
DOI: 10.1101/2025.10.07.680916

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