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Article

Mitochondrial complex-derived ROS induces lysosomal dysfunction and impairs autophagic flux in human cells carrying the APOE4 allele.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jun 2026

Niño Sandra A, Barrios-Camus Oskar, Silva-Pavez Eduardo, Cárdenas J César, González-Billault Christian

Abstract excerpt

The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer's disease (sAD), yet its cell-autonomous effects remain poorly understood. While young, asymptomatic APOE4 carriers exhibit abnormal brain metabolism, the mechanistic link between mitochondrial dysfunction and lysosomal-autophagic failure remains unclear. In this study, we conducted a comprehensive analysis of primary human fibroblasts...

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Identifiers

PMID: 41785939
DOI: 10.1016/j.bbadis.2026.168211

Genes

TOMM20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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