Article
Apolipoprotein E Isoforms and AMD.
Advances in experimental medicine and biology - 1 Jan 2016
Toops Kimberly A, Tan Li Xuan, Lakkaraju Aparna
Abstract excerpt
The cholesterol transporting protein apolipoprotein E (ApoE) occurs in three allelic variants in humans unlike in other species. The resulting protein isoforms E2, E3 and E4 exhibit differences in lipid binding, integrating into lipoprotein particles and affinity for lipoprotein receptors. ApoE isoforms confer genetic risk for several diseases of aging including atherosclerosis, Alzheimer's disease, and...
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