Article
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
Nature neuroscience - 1 Nov 2014
Molosh Andrei I, Johnson Philip L, Spence John P, Arendt David, Federici Lauren M, Bernabe Cristian, Janasik Steven P, Segu Zaneer M, Khanna Rajesh, Goswami Chirayu, Zhu Weiguo, Park Su-Jung, Li Lang, Mechref Yehia S, Clapp D Wade, Shekhar Anantha
Abstract excerpt
Children with neurofibromatosis type 1 (NF1) are increasingly recognized as having a high prevalence of social difficulties and autism spectrum disorders (ASDs). We demonstrated a selective social learning deficit in mice with deletion of a single Nf1 allele (Nf1(+/-)), along with greater activation of the mitogen-activated protein kinase pathway in neurons from the amygdala and frontal cortex, structures that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.